Purpose: The aim of this study is to evaluate the role of ultrasonography in different diagnostic conditions of abdomen. Methodology: In this prospective study 55 male patients of USG abdomen were included and stat for result was mean and percentage stats used. Result: out of 80 male patients, out of which 19 (23.75%) patients have fatty liver, 11 (13.75%) patients have right renal calculus, 8 (10%)patient have left renal calculus, 3(3.75%)patient have B/L renal calculus, 4 (5%) patients have acute pancreatitis, 3 (3.75%) patients have acute appendicitis, 2 (2.5%) patients have liver abscess, 6 (7.5%) patients have cyst, 6 (7.5%) patients have ascites, 17 (21.25%) patients have cholelithiasis and 1 (1.25%) patient have normal. Sonography play key role in to visualized gross primary investigation in abdomen. Conclusion: The study concludes uses of USG should be perform as a primary investigation for all patients. This study has shown a relatively high sensitivity, specificity and diagnostic accuracy of USG in cases of acute abdomen in a careful hand. USG is currently considered the preferred initial imaging technique for patients who are clinically suspected of having fatty liver, renal calculus, acute pancreatitis, acute appendicitis, ascites, cyst, liver abscess and cholelithiasis etc.