Background: This article tells us about importance of General pathology in homoeopathy, and also gives us clear idea about the concept of miasm and micro-organisms and also about the drug disease and toxicology. Methods: Various old literatures and previous journals about temperaments and its philosophical background in relevance to Homoeopathy is reviewed and thus the importance of General Pathology in Homoeopathic practice is explained as per Stuart Close in this article. Conclusion: Helps the Homoeopath to know the clearly about the role of General Pathology in Homoeopathy and also answers the question such as is miasm and micro-organism one and the same.