Gallbladder carcinoma is the most common biliary system malignancy with females predominance. Clinically it presents with vague symptoms or remains clinically silent until it has spread to adjacent organs, which leads to delay in early diagnosis and treatment. It is frequently identified incidentally by final pathology after routine cholecystectomy or discovered intraoperatively or when complications occur due to invasion of adjacent organs, which is an advanced stage.

Ultrasonography is usually used as initial modality of investigation in a suspected gallbladder pathology but for accurate diagnosis, staging and management high resolution cross-sectional imaging like CT with contrast or magnetic resonance imaging (MRI) is recommended.

Settings and Designs: It is a prospective diagnostic study on 200 patients with sonographically/ clinically suspected gallbladder carcinoma. GE 32 slice Multi Detector Computed Tomography (MDCT) machine and non ionic iodinated water soluble contrast medium (Omnipaque TM) was used in the study.

Results: For gall bladder cancer (GB fossa mass) CT had 100% sensitivity, 73.08% specificity, 96.13% positive predictive value, and 100% negative predictive value. CT's gallbladder cancer diagnostic sensitivity was 100%, specificity 84.62%, positive predictive value 95.92%, and negative predictive value 100%.