There is lack of data related to dental occlusion amongst patients cured from radiotherapy. The aim of our review was to highlight the long-term effects of radiotherapy on the craniofacial skeleton and dentition. The complication of malocclusion following radiotherapy in paediatric population has been well documented but a similar incidence in adults has not been given any importance in the present literature. It is important to understand the fundamental disease, its treatment protocols, effects on growing skeleton, dental development, bone, and tooth movement.