Background and Purpose: Breast pain is one of the most common symptoms experienced by women and a frequent reason of health care including imaging. The purpose of the present study was to evaluate the breast pain with mammography and ultrasound, cause of the breast pain in women. Methodology: The study reviewed 30 numbers of articles. Google Scholars and pubmed were searched for the relevant studies. Data was taken according to the age/sex, symptoms, menopausal status, clinical history and imaging modalities. Result: This review article provide the information about risk of malignancy with breast pain depend upon the type of mastalgia. Patients with non-cyclic pain showed high severity of malignancy. There is no risk of cancer in patients presenting with pain. The negative predictive value of both the mammography and ultrasound with breast pain was 100% or around it. Conclusion: Breast imaging can help to determine the cause of breast pain if there is an underlying and operable cause. Ultrasound and mammography should be done on the basis of age of the patient. The accuracy of mammogram increased in women with less dense and fattier breast and in younger patient ultrasound appear superior to mammogram. Imaging modalities can reassure the patients that they do not have any pathological findings and the severity of pain and anxiety decreased after ultrasound.