Background: Intravenous Urography is useful technique and use for the evaluation of pathology of the urinary tract with the help of ionizing radiation and contrast media. It includes control/scout film of the abdomen and post contrast films at the serial intervals. Aim: this study is to evaluate the role of IVU under fluoroscopy in different diagnostic conditions. Methodology: A quantitative prospective study conducted on 40 patients, who underwent IVU procedure. Consent form, History and symptoms were obtained from the patient prior to the investigation. Results: The result shows that total 40 patient is selected in which 30 (75%) patients have findings and 10 (25%) patients have normal study. 34 (85%) patients have normal functioning right kidney and 6 (15%) have delayed functioning. In the left side kidney, there are 34 (85%) normal functioning, 4 (10%) delayed and 2 (5%) non-functioning kidneys are found. Right side calculus, right hydronephrosis, left side calculus, left hydronephrosis are shown in 15(37.5%), 10 (25%), 8 (20%), 3 (7.5%) respectively. Left PUJ calculus is shown in 2 (5%) patients, Left VUJ calculus is in 2 (5%) patients and left ureteric calculi are seen in 2 (5%) patients. Conclusions: The study concludes uses of IVU should not be consider as primary investigation for renal anomalies. Ultrasonography should be performed as a primary investigation. Patient with long-standing symptoms is more likely to diagnosed pathology in IVU. For the radiolucent calculus, IVU found gold standard procedures as compared to sonography.