Background This article aims to comprehensively describe indications, contraindications, technical aspects, diagnostic accuracy and complications of percutaneous lung biopsy. Methods and Materials: Fine-needle aspiration biopsy (FNAB) and core-needle biopsy (CNB) currently is the predominant method for obtaining tissue specimens in patients with lung lesions. In many cases treatment protocols are based on histological information. In 85 of all 97 patients included in ours study FNAB biopsy is performed and in 12 patients (CNB), when technically feasible, or in cases where other techniques (such as bronchoscopy with lavage) are inconclusive. The 19-22G disposable needles were used. Results In all 97 patients, aged 19-69 years with pulmonary lesions with dimensions of 2.0 cm or less FNB under CT control are performed. In 15 cases FNA under US control are performed due to the superficial localization of the lesions. Cytological and histhological evaluation of FNAB samples were performed in all patients. Diagnostic sensitivity and accuracy are calculated. Assess the nusmber and type of complications that occurred. Fine-needle aspiration biopsy (FNAB) and core-needle biopsy (CNB), with the latter demonstrated to have a slightly higher overall sensitivity, specificity and accuracy. Conclusion Percutaneous fine-needle aspiration biopsy (FNAB) and core-needle biopsy (CNB) are safe procedures even though a few complications are possible: pneumothorax, pulmonary haemorrhage and haemoptysis witch are common, while air embolism and seeding are rare, but with severe consequences.